L-carnitine deficiency severely impairs the mitochondrial import of long-chain acyl-CoAs, directly limiting the acetyl-CoA pool required for ketogenesis ( -oxidation activity ( Figure 2 The preterm brain exhibits extraordinarily high energy demands to fuel rapid growth and development, demands which can surpass the capacity of glucose supply alone
Regulation of Ferroptotic Cancer Cell Death by Gpx4
Assay: GSH/GSSG in mouse HNC cells and cancer tissue
There are two main types of kidney disease: Chronic Kidney Disease (CKD) : A gradual loss of kidney function over time, often due to diabetes or high blood pressure
Modeling Structures of di-domain GPDHs using AlphaFold We used web-based AlphaFold interface to model full-length structures of di-domain glycerol-3-phosphate dehydrogenases (GPDHs) from Dunaliella viridis (GenBank: ACD84644.1) , Dunaliella salina (GenBank: AAX56341.1) , Chlamydomonas reinhardtii (GenBank: XP_042919880.1), and Sphaeroforma arctica (GenBank: XP_014155909.1) ( Supplementary Figure S2 ) 5557
Due to high sequence similarity and presence of evolutionarily conserved sequence domains ( Figure 8A ), we suggest structural and functional similarity of IIGP1 and the members of the INF-I GTPase family analyzed in this section
